Regulatory Network in Protein Phosphorylation
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Substrate: KRT18

Description: Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18)(K18) (Cell proliferation-inducing gene 46 protein).

Synonyms: CYK18

Ensembl ID: ENSG00000111057

UniprotKB/SwissProt: K1C18_HUMAN (P05783)

Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, perinuclear region.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of KRT18

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1KRT18K1C18_HUMANS7SFTTR S TFSTN 31.54% Swiss-Prot 55.0 View   
2KRT18K1C18_HUMANS7SFTTR S TFSTN 31.54% Phospho.ELM 7.0View   
3KRT18K1C18_HUMANT8FTTRS T FSTNY 20.51% Swiss-Prot 55.0 (Similarity)View   
4KRT18K1C18_HUMANT11RSTFS T NYRSL 31.88% Swiss-Prot 55.0 (Similarity)View   
5KRT18K1C18_HUMANS15STNYR S LGSVQ 27.07% Swiss-Prot 55.0 View   
6KRT18K1C18_HUMANS18YRSLG S VQAPS 19.15% Swiss-Prot 55.0 View   
7KRT18K1C18_HUMANS30GARPV S SAASV 19.55% Swiss-Prot 55.0 (Similarity)View   
8KRT18K1C18_HUMANS31ARPVS S AASVY 28.26% Swiss-Prot 55.0 (Similarity)View   
9KRT18K1C18_HUMANS34VSSAA S VYAGA 18.51%CDC2 HPRD:01020(in vivo)  ViewAnalyzing
10KRT18K1C18_HUMANS34VSSAA S VYAGA 18.51%CDC2 Swiss-Prot 55.0   ViewAnalyzing
11KRT18K1C18_HUMANS34VSSAA S VYAGA 18.51%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
12KRT18K1C18_HUMANY36SAASV Y AGAGG 9.23% Swiss-Prot 55.0 (Similarity)View   
13KRT18K1C18_HUMANS42AGAGG S GSRIS 32.45% Swiss-Prot 55.0 (Similarity)View   
14KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%RSK2 HPRD:01020(in vitro)  ViewAnalyzing
15KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%p70S6Kb Phospho.ELM 7.0  ViewAnalyzing
16KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%PKCe(PKC epsilon) Phospho.ELM 7.0 ViewAnalyzing
17KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%PKCa HPRD:01020(in vitro)  ViewAnalyzing
18KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%PKC_group Phospho.ELM 7.0 ViewAnalyzing
19KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%CaMK1a Phospho.ELM 7.0  ViewAnalyzing
20KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%CaMK2a HPRD:01020(in vitro)  ViewAnalyzing
21KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%PKCe HPRD:01020(in vitro)  ViewAnalyzing
22KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%CaMK2_group Phospho.ELM 7.0 ViewAnalyzing
23KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%AurA(STK6) Swiss-Prot 55.0  ViewAnalyzing
24KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%CaMK_group Swiss-Prot 55.0  ViewAnalyzing
25KRT18K1C18_HUMANS53VSRST S FRGGM 17.75%PKCe Swiss-Prot 55.0   ViewAnalyzing
26KRT18K1C18_HUMANS60RGGMG S GGLAT 22.31% Swiss-Prot 55.0 View   
27KRT18K1C18_HUMANS401LDSSN S MQTIQ 17.76% Swiss-Prot 55.0 (Similarity)View   
28KRT18K1C18_HUMANT404SNSMQ T IQKTT 19.41% Swiss-Prot 55.0 (Similarity)View