Regulatory Network in Protein Phosphorylation
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Substrate: MET

Description: Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGFreceptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor)(Met proto-oncogene tyrosine kinase) (c-Met).

Ensembl ID: ENSG00000105976

UniprotKB/SwissProt: MET_HUMAN (P08581)

Function: Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:1FYR
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MET

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1METMET_HUMANY830GILSK Y FDLIY 10.03% Phospho.ELM 7.0View   
2METMET_HUMANT977DARVH T PHLDR 15.00% Phospho.ELM 7.0View   
3METMET_HUMANT977DARVH T PHLDR 15.00% Swiss-Prot 55.0 View   
4METMET_HUMANS985LDRLV S ARSVS 23.66% HPRD:01280(in vitro)View   
5METMET_HUMANS985LDRLV S ARSVS 23.66%PKC_group Phospho.ELM 7.0 ViewAnalyzing
6METMET_HUMANS985LDRLV S ARSVS 23.66%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
7METMET_HUMANS985LDRLV S ARSVS 23.66%PKCe(PKC epsilon) Phospho.ELM 7.0 ViewAnalyzing
8METMET_HUMANS988LVSAR S VSPTT 27.02% Phospho.ELM 7.0View   
9METMET_HUMANS988LVSAR S VSPTT 27.02% Swiss-Prot 55.0 View   
10METMET_HUMANS990SARSV S PTTEM 20.13% Swiss-Prot 55.0 View   
11METMET_HUMANS990SARSV S PTTEM 20.13% Phospho.ELM 7.0View   
12METMET_HUMANY1003NESVD Y RATFP 10.45% Phospho.ELM 7.0View   
13METMET_HUMANY1003NESVD Y RATFP 10.45% HPRD:01280(in vivo)View   
14METMET_HUMANY1003NESVD Y RATFP 10.45% Swiss-Prot 55.0 View   
15METMET_HUMANY1230LARDM Y DKEYY 28.31% HPRD:01280(in vitro)View   
16METMET_HUMANY1230LARDM Y DKEYY 28.31%Met Phospho.ELM 7.0  ViewAnalyzing
17METMET_HUMANY1234MYDKE Y YSVHN 13.54% HPRD:01280(in vivo)View   
18METMET_HUMANY1234MYDKE Y YSVHN 13.54%Met Phospho.ELM 7.0  ViewAnalyzing
19METMET_HUMANY1235YDKEY Y SVHNK 12.81% HPRD:01280(in vitro)View   
20METMET_HUMANY1235YDKEY Y SVHNK 12.81%Met Phospho.ELM 7.0  ViewAnalyzing
21METMET_HUMANY1235YDKEY Y SVHNK 12.81%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
22METMET_HUMANY1295FDITV Y LLQGR 7.95% HPRD:01280(in vitro)View   
23METMET_HUMANY1313CPDPL Y EVMLK 16.33% Phospho.ELM 7.0View   
24METMET_HUMANS1331MRPSF S ELVSR 34.07% HPRD:01280(in vitro)View   
25METMET_HUMANS1338LVSRI S AIFST 17.75% HPRD:01280(in vitro)View   
26METMET_HUMANY1349FIGEH Y VHVNA 6.48%Met Phospho.ELM 7.0  ViewAnalyzing
27METMET_HUMANY1349FIGEH Y VHVNA 6.48% HPRD:01280(in vivo)View   
28METMET_HUMANY1356HVNAT Y VNVKC 6.39% Swiss-Prot 55.0 View   
29METMET_HUMANY1356HVNAT Y VNVKC 6.39% HPRD:01280(in vivo)View   
30METMET_HUMANY1356HVNAT Y VNVKC 6.39%Met Phospho.ELM 7.0  ViewAnalyzing
31METMET_HUMANY1365KCVAP Y PSLLS 8.84% Phospho.ELM 7.0View   
32METMET_HUMANY1365KCVAP Y PSLLS 8.84% HPRD:01280(in vitro)View