Regulatory Network in Protein Phosphorylation
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Substrate: MUC1

Description: Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)].

Synonyms: PUM

UniprotKB/SwissProt: MUC1_HUMAN (P15941)

Function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, Src and NF- kappaB pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MUC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MUC1MUC1_HUMANT224TSAPD T RPAPG 37.18%PKCd HPRD:01152(in vitro;in vivo)  ViewAnalyzing
2MUC1MUC1_HUMANY1203PARDT Y HPMSE 14.28% Phospho.ELM 7.0View   
3MUC1MUC1_HUMANY1203PARDT Y HPMSE 14.28%PDGFR_group Swiss-Prot 55.0  ViewAnalyzing
4MUC1MUC1_HUMANY1212SEYPT Y HTHGR 10.54% Phospho.ELM 7.0View   
5MUC1MUC1_HUMANY1218HTHGR Y VPPSS 23.15%PDGFR_group Swiss-Prot 55.0  ViewAnalyzing
6MUC1MUC1_HUMANT1224VPPSS T DRSPY 39.51%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
7MUC1MUC1_HUMANT1224VPPSS T DRSPY 39.51%PKCd Swiss-Prot 55.0   ViewAnalyzing
8MUC1MUC1_HUMANT1224VPPSS T DRSPY 39.51%PKCd HPRD:01152(in vitro;in vivo)  ViewAnalyzing
9MUC1MUC1_HUMANS1227SSTDR S PYEKV 34.34%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
10MUC1MUC1_HUMANS1227SSTDR S PYEKV 34.34%GSK3B HPRD:01152(in vitro)  ViewAnalyzing
11MUC1MUC1_HUMANS1227SSTDR S PYEKV 34.34%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
12MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%ZAP70 HPRD:01152(in vitro)  ViewAnalyzing
13MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%EGFR HPRD:01152(in vivo)  ViewAnalyzing
14MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%EGFR HPRD:01152(in vitro;in vivo)  ViewAnalyzing
15MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%EGFR Phospho.ELM 7.0  ViewAnalyzing
16MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%Src Phospho.ELM 7.0  ViewAnalyzing
17MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%SRC Swiss-Prot 55.0   ViewAnalyzing
18MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%EGFR Swiss-Prot 55.0   ViewAnalyzing
19MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%CSK Swiss-Prot 55.0   ViewAnalyzing
20MUC1MUC1_HUMANY1243GSSLS Y TNPAV 18.81% HPRD:01152(in vivo)View   
21MUC1MUC1_HUMANY1243GSSLS Y TNPAV 18.81% HPRD:01152(in vivo)View   
22MUC1MUC1_HUMANY1243GSSLS Y TNPAV 18.81%ABL1 Phospho.ELM 7.0  ViewAnalyzing