Regulatory Network in Protein Phosphorylation
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Substrate: NCF4

Description: Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor4) (p40-phox) (p40phox) (SH3 and PX domain-containing protein 4).

Synonyms: SH3PXD4

Ensembl ID: ENSG00000100365

UniprotKB/SwissProt: NCF4_HUMAN (Q15080)

Function: Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:1H6H
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NCF4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NCF4NCF4_HUMANT154RLRPR T RKVKS 37.21% Swiss-Prot 55.0 View   
2NCF4NCF4_HUMANT154RLRPR T RKVKS 37.21%PKCd HPRD:03289(in vitro;in vivo)  ViewAnalyzing
3NCF4NCF4_HUMANT154RLRPR T RKVKS 37.21%PKC_group Phospho.ELM 7.0 ViewAnalyzing
4NCF4NCF4_HUMANT154RLRPR T RKVKS 37.21%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
5NCF4NCF4_HUMANS315ARGLP S QKRLF 54.07% Swiss-Prot 55.0 View   
6NCF4NCF4_HUMANS315ARGLP S QKRLF 54.07%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing