|Description: Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcriptioncomplex cytosolic component) (NF-ATc1) (NF-ATc) (NFATc).|
Synonyms: NFAT2, NFATC
Ensembl ID: ENSG00000131196
UniprotKB/SwissProt: NFAC1_HUMAN (O95644)
Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sust