Regulatory Network in Protein Phosphorylation
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Substrate: NFATC1

Description: Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcriptioncomplex cytosolic component) (NF-ATc1) (NF-ATc) (NFATc).

Synonyms: NFAT2, NFATC

Ensembl ID: ENSG00000131196

UniprotKB/SwissProt: NFAC1_HUMAN (O95644)

Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sust
PDB:1A66
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NFATC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NFATC1NFAC1_HUMANS117APALE S PRIEI 21.96% Swiss-Prot 55.0 View   
2NFATC1NFAC1_HUMANS245TSPRA S VTEES 30.74%PKA_group Phospho.ELM 7.0 ViewAnalyzing
3NFATC1NFAC1_HUMANS245TSPRA S VTEES 30.74%PKCa HPRD:02729(in vitro)  ViewAnalyzing
4NFATC1NFAC1_HUMANS256WLGAR S SRPAS 30.11%PKCa HPRD:02729(in vitro)  ViewAnalyzing
5NFATC1NFAC1_HUMANS269NKRKY S LNGRQ 20.56%PKA_group Phospho.ELM 7.0 ViewAnalyzing
6NFATC1NFAC1_HUMANS269NKRKY S LNGRQ 20.56%PKCa HPRD:02729(in vitro)  ViewAnalyzing
7NFATC1NFAC1_HUMANS294GSPRV S VTDDS 22.15%PKA_group Phospho.ELM 7.0 ViewAnalyzing
8NFATC1NFAC1_HUMANS294GSPRV S VTDDS 22.15%PKCa HPRD:02729(in vitro)  ViewAnalyzing