|Description: Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2)(NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2)(HEBP1).|
Ensembl ID: ENSG00000116044
UniprotKB/SwissProt: NF2L2_HUMAN (Q16236)
Function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.