Regulatory Network in Protein Phosphorylation
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Substrate: NFE2L2

Description: Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2)(NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2)(HEBP1).

Synonyms: NRF2

Ensembl ID: ENSG00000116044

UniprotKB/SwissProt: NF2L2_HUMAN (Q16236)

Function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
PDB:2FLU
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NFE2L2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NFE2L2NF2L2_HUMANS40EVFDF S QRRKE 25.31%PKC_group Swiss-Prot 55.0  ViewAnalyzing
2NFE2L2NF2L2_HUMANS40EVFDF S QRRKE 25.31%PKCd HPRD:02732(in vitro)  ViewAnalyzing
3NFE2L2NF2L2_HUMANS40EVFDF S QRRKE 25.31%PKC_group Phospho.ELM 7.0 ViewAnalyzing