Regulatory Network in Protein Phosphorylation
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Substrate: NOS1

Description: Nitric oxide synthase, brain (EC 1.14.13.39) (NOS type I) (NeuronalNOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

Ensembl ID: ENSG00000089250

UniprotKB/SwissProt: NOS1_HUMAN (P29475)

Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NOS1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%CaMK4 Phospho.ELM 7.0  ViewAnalyzing
2NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%CaMK4 HPRD:01226(in vitro)  ViewAnalyzing
3NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%PKC_group Phospho.ELM 7.0 ViewAnalyzing
4NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%PKACa HPRD:01226(in vitro)  ViewAnalyzing
5NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%PKCa HPRD:01226(in vitro)  ViewAnalyzing
6NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%CaMK1a HPRD:01226(in vitro)  ViewAnalyzing
7NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%CaMK1a Phospho.ELM 7.0  ViewAnalyzing
8NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%PKA_group Phospho.ELM 7.0 ViewAnalyzing
9NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
10NOS1NOS1_HUMANS852KVRFN S VSSYS 22.21%CaMK2a HPRD:01226(in vitro)  ViewAnalyzing
11NOS1NOS1_HUMANS1417RLRSE S IAFIE 22.06% HPRD:01226(in vitro)View   
12NOS1NOS1_HUMANS1417RLRSE S IAFIE 22.06% Phospho.ELM 7.0View