|Description: Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4homolog) (hG4-1) (ErbB3-binding protein 1).|
Ensembl ID: ENSG00000170515
UniprotKB/SwissProt: PA2G4_HUMAN (Q9UQ80)
Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Note=Tranlocates to the nucleus upon treatment with HRG.