Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinase PKCi]
Substrate: PA2G4

Description: Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4homolog) (hG4-1) (ErbB3-binding protein 1).

Synonyms: EBP1

Ensembl ID: ENSG00000170515

UniprotKB/SwissProt: PA2G4_HUMAN (Q9UQ80)

Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Note=Tranlocates to the nucleus upon treatment with HRG.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PA2G4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PA2G4PA2G4_HUMANS2----M S GEDEQ 51.38% Swiss-Prot 55.0 View   
2PA2G4PA2G4_HUMANS2----M S GEDEQ 51.38% Phospho.ELM 7.0View   
3PA2G4PA2G4_HUMANS363LQSSA S RKTQK 35.94%PKCb HPRD:03685(in vitro;in vivo)  ViewAnalyzing
4PA2G4PA2G4_HUMANS363LQSSA S RKTQK 35.94%PKCa HPRD:03685(in vitro;in vivo)  ViewAnalyzing
5PA2G4PA2G4_HUMANS363LQSSA S RKTQK 35.94%PKCg HPRD:03685(in vitro;in vivo)  ViewAnalyzing
6PA2G4PA2G4_HUMANT366SASRK T QKKKK 44.50% Swiss-Prot 55.0 (Probable)View   
7PA2G4PA2G4_HUMANT366SASRK T QKKKK 44.50%PKCg HPRD:03685(in vitro;in vivo)  ViewAnalyzing
8PA2G4PA2G4_HUMANT366SASRK T QKKKK 44.50%PKCa HPRD:03685(in vitro;in vivo)  ViewAnalyzing
9PA2G4PA2G4_HUMANT366SASRK T QKKKK 44.50%PKCb HPRD:03685(in vitro;in vivo)  ViewAnalyzing
10PA2G4PA2G4_HUMANT386ATSGE T LEENE 42.89% Swiss-Prot 55.0 View   
11PA2G4PA2G4_HUMANT386ATSGE T LEENE 42.89% Phospho.ELM 7.0View