|Description: Peptidyl-glycine alpha-amidating monooxygenase precursor (PAM)[Includes: Peptidylglycine alpha-hydroxylating monooxygenase(EC 126.96.36.199) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidatinglyase (EC 188.8.131.52) (Peptidylamidoglycolate lyase) (PAL)].|
Ensembl ID: ENSG00000145730
UniprotKB/SwissProt: AMD_HUMAN (P19021)
Function: Bifunctional enzyme that catalyzes 2 sequencial steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Note=Secreted from secretory granules. Isoform 4: Secreted. Note=Secreted from secretory granules.