Regulatory Network in Protein Phosphorylation
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Substrate: PLCB1

Description: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

Synonyms: KIAA0581

Ensembl ID: ENSG00000182621

UniprotKB/SwissProt: PLCB1_HUMAN (Q9NQ66)

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PLCB1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PLCB1PLCB1_HUMANT333NSSHN T YLTAG 17.93% Swiss-Prot 55.0 (Similarity)View   
2PLCB1PLCB1_HUMANY334SSHNT Y LTAGQ 13.84% Swiss-Prot 55.0 (Similarity)View   
3PLCB1PLCB1_HUMANT336HNTYL T AGQLA 20.51% Swiss-Prot 55.0 (Similarity)View   
4PLCB1PLCB1_HUMANS569SFEMS S FVETK 31.81% Swiss-Prot 55.0 View   
5PLCB1PLCB1_HUMANT573SSFVE T KGLEQ 25.72% Swiss-Prot 55.0 View   
6PLCB1PLCB1_HUMANS887QPAPG S VKAPA 21.27%PKC_group Phospho.ELM 7.0 ViewAnalyzing
7PLCB1PLCB1_HUMANS887QPAPG S VKAPA 21.27%PKCa HPRD:06177(in vivo)  ViewAnalyzing
8PLCB1PLCB1_HUMANS887QPAPG S VKAPA 21.27%PKCd HPRD:06177(in vivo)  ViewAnalyzing
9PLCB1PLCB1_HUMANS887QPAPG S VKAPA 21.27%PKC_group  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
10PLCB1PLCB1_HUMANS982KSEPS S PDHGS 45.09%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
11PLCB1PLCB1_HUMANS982KSEPS S PDHGS 45.09% HPRD:06177(in vivo)View   
12PLCB1PLCB1_HUMANS982KSEPS S PDHGS 45.09%Erk1 HPRD:06177(in vivo)  ViewAnalyzing