Regulatory Network in Protein Phosphorylation
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Substrate: PLD1

Description: Phospholipase D1 (EC 3.1.4.4) (PLD 1) (Choline phosphatase 1)(Phosphatidylcholine-hydrolyzing phospholipase D1) (hPLD1).

Ensembl ID: ENSG00000075651

UniprotKB/SwissProt: PLD1_HUMAN (Q13393)

Function: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, perinuclear region (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Late endosome (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PLD1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PLD1PLD1_HUMANS2----M S LKNEP 60.39%PKCa HPRD:03855(in vivo)  ViewAnalyzing
2PLD1PLD1_HUMANT147PTRRH T FRRQN 19.61%PKCa HPRD:03855(in vivo)  ViewAnalyzing
3PLD1PLD1_HUMANS561KFSKF S LYKQL 34.23%PKCa HPRD:03855(in vivo)  ViewAnalyzing
4PLD1PLD1_HUMANS629TGSIR S LQTGV 24.14% Swiss-Prot 55.0 View   
5PLD1PLD1_HUMANS629TGSIR S LQTGV 24.14% Phospho.ELM 7.0View