Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinase PKCi]
Substrate: PPP1R14A

Description: Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiatedinhibitory protein of PP1) (CPI-17).

Synonyms: CPI17, PPP1INL

Ensembl ID: ENSG00000167641

UniprotKB/SwissProt: PP14A_HUMAN (Q96A00)

Function: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PPP1R14A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PPP1R14APP14A_HUMANS12GKRVL S KLQSP 28.59%DAPK3 Phospho.ELM 7.0  ViewAnalyzing
2PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01% Swiss-Prot 55.0 (Similarity)View   
3PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing
4PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKA_group Phospho.ELM 7.0 ViewAnalyzing
5PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%DAPK3 Phospho.ELM 7.0  ViewAnalyzing
6PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%ILK Phospho.ELM 7.0  ViewAnalyzing
7PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKCa HPRD:16291(in vitro;in vivo)  ViewAnalyzing
8PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKD1 HPRD:16291(in vitro;in vivo)  ViewAnalyzing
9PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKD1 Phospho.ELM 7.0  ViewAnalyzing
10PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
11PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKCe HPRD:16291(in vitro;in vivo)  ViewAnalyzing
12PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKCe(PKC epsilon) Phospho.ELM 7.0 ViewAnalyzing
13PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%PKCz HPRD:16291(in vitro;in vivo)  ViewAnalyzing
14PPP1R14APP14A_HUMANT38RHARV T VKYDR 13.01%CaMK2_group Phospho.ELM 7.0 ViewAnalyzing
15PPP1R14APP14A_HUMANS130RQPSP S HDGSL 38.25%CaMK2a Phospho.ELM 7.0  ViewAnalyzing