Regulatory Network in Protein Phosphorylation
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Substrate: PRKCA

Description: Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

Synonyms: PKCA, PRKACA

Ensembl ID: ENSG00000154229

UniprotKB/SwissProt: KPCA_HUMAN (P17252)

Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PRKCA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PRKCAKPCA_HUMANS226PQWNE S FTFKL 26.77% Swiss-Prot 55.0 View   
2PRKCAKPCA_HUMANS226PQWNE S FTFKL 26.77% Phospho.ELM 7.0View   
3PRKCAKPCA_HUMANS319GNKVI S PSEDR 25.92% Swiss-Prot 55.0 View   
4PRKCAKPCA_HUMANS319GNKVI S PSEDR 25.92% Phospho.ELM 7.0View   
5PRKCAKPCA_HUMANT494MMDGV T TRTFC 18.98% Swiss-Prot 55.0 (Similarity)View   
6PRKCAKPCA_HUMANT495MDGVT T RTFCG 25.88% Swiss-Prot 55.0 (Similarity)View   
7PRKCAKPCA_HUMANT497GVTTR T FCGTP 22.61% Phospho.ELM 7.0View   
8PRKCAKPCA_HUMANT497GVTTR T FCGTP 22.61% Swiss-Prot 55.0 View   
9PRKCAKPCA_HUMANT501RTFCG T PDYIA 17.73% Phospho.ELM 7.0View   
10PRKCAKPCA_HUMANT501RTFCG T PDYIA 17.73% Swiss-Prot 55.0 View   
11PRKCAKPCA_HUMANT631FDKFF T RGQPV 36.70%autocatalysis  Swiss-Prot 55.0 (Potential) ViewAnalyzing
12PRKCAKPCA_HUMANT638GQPVL T PPDQL 32.77% Phospho.ELM 7.0View   
13PRKCAKPCA_HUMANT638GQPVL T PPDQL 32.77%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
14PRKCAKPCA_HUMANS657DFEGF S YVNPQ 38.74%PKCz HPRD:01498(in vitro;in vivo)  ViewAnalyzing
15PRKCAKPCA_HUMANS657DFEGF S YVNPQ 38.74%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
16PRKCAKPCA_HUMANS657DFEGF S YVNPQ 38.74% Swiss-Prot 55.0 (Similarity)View   
17PRKCAKPCA_HUMANY658FEGFS Y VNPQF 11.28%Syk Phospho.ELM 7.0  ViewAnalyzing
18PRKCAKPCA_HUMANY658FEGFS Y VNPQF 11.28% Swiss-Prot 55.0 View   
19PRKCAKPCA_HUMANY658FEGFS Y VNPQF 11.28%SYK HPRD:01498(in vitro)  ViewAnalyzing