|Description: Protein kinase C alpha type (EC 220.127.116.11) (PKC-alpha) (PKC-A).|
Synonyms: PKCA, PRKACA
Ensembl ID: ENSG00000154229
UniprotKB/SwissProt: KPCA_HUMAN (P17252)
Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: