Regulatory Network in Protein Phosphorylation
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Substrate: PRKCQ

Description: Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

Synonyms: PRKCT

Ensembl ID: ENSG00000065675

UniprotKB/SwissProt: KPCT_HUMAN (Q04759)

Function: This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1XJD
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PRKCQ

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PRKCQKPCT_HUMANY90TTVEL Y SLAER 6.53%Lck Phospho.ELM 7.0  ViewAnalyzing
2PRKCQKPCT_HUMANY90TTVEL Y SLAER 6.53%LCK HPRD:02710(in vitro;in vivo)  ViewAnalyzing
3PRKCQKPCT_HUMANT219INSRE T MFHKE 24.83%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
4PRKCQKPCT_HUMANT219INSRE T MFHKE 24.83%PKCt HPRD:02710(in vivo)  ViewAnalyzing
5PRKCQKPCT_HUMANT219INSRE T MFHKE 24.83%PKCt(PKC theta) Phospho.ELM 7.0 ViewAnalyzing
6PRKCQKPCT_HUMANT538DAKTN T FCGTP 26.07% HPRD:02710(in vitro)View   
7PRKCQKPCT_HUMANT538DAKTN T FCGTP 26.07% Swiss-Prot 55.0 View   
8PRKCQKPCT_HUMANT538DAKTN T FCGTP 26.07% Phospho.ELM 7.0View   
9PRKCQKPCT_HUMANS676EKPRL S FADRA 21.48% HPRD:02710(in vitro)View   
10PRKCQKPCT_HUMANS676EKPRL S FADRA 21.48% Swiss-Prot 55.0 View   
11PRKCQKPCT_HUMANS676EKPRL S FADRA 21.48% Phospho.ELM 7.0View   
12PRKCQKPCT_HUMANS685RALIN S MDQNM 19.42% Phospho.ELM 7.0View   
13PRKCQKPCT_HUMANS685RALIN S MDQNM 19.42% Swiss-Prot 55.0 View   
14PRKCQKPCT_HUMANS695MFRNF S FMNPG 27.43% Phospho.ELM 7.0View   
15PRKCQKPCT_HUMANS695MFRNF S FMNPG 27.43% Swiss-Prot 55.0 View   
16PRKCQKPCT_HUMANS695MFRNF S FMNPG 27.43% HPRD:02710(in vitro)View