Regulatory Network in Protein Phosphorylation
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Substrate: PRKCZ

Description: Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

Synonyms: PKC2

Ensembl ID: ENSG00000067606

UniprotKB/SwissProt: KPCZ_HUMAN (Q05513)

Function: This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Endosome. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PRKCZ

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PRKCZKPCZ_HUMANS223SRKHD S IKDDS 31.12% Swiss-Prot 55.0 View   
2PRKCZKPCZ_HUMANS223SRKHD S IKDDS 31.12% Phospho.ELM 7.0View   
3PRKCZKPCZ_HUMANT410GDTTS T FCGTP 22.35%PDK1 Swiss-Prot 55.0   ViewAnalyzing
4PRKCZKPCZ_HUMANT410GDTTS T FCGTP 22.35%PDK1 Phospho.ELM 7.0  ViewAnalyzing
5PRKCZKPCZ_HUMANT410GDTTS T FCGTP 22.35%PDK1 HPRD:01504(in vitro)  ViewAnalyzing
6PRKCZKPCZ_HUMANT560EPVQL T PDDED 13.95% Swiss-Prot 55.0 (Similarity)View   
7PRKCZKPCZ_HUMANT560EPVQL T PDDED 13.95%PKCz HPRD:01504(in vitro)  ViewAnalyzing
8PRKCZKPCZ_HUMANT560EPVQL T PDDED 13.95%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing