Regulatory Network in Protein Phosphorylation
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Substrate: PTGER4

Description: Prostaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) (PGEreceptor, EP4 subtype).

Synonyms: PTGER2

Ensembl ID: ENSG00000171522

UniprotKB/SwissProt: PE2R4_HUMAN (P35408)

Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PTGER4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PTGER4PE2R4_HUMANS222FMRRT S LGTEQ 24.00%PKA_group Phospho.ELM 7.0 ViewAnalyzing
2PTGER4PE2R4_HUMANS259FRRRR S FRRIA 22.69%PKA_group Phospho.ELM 7.0 ViewAnalyzing
3PTGER4PE2R4_HUMANS259FRRRR S FRRIA 22.69%PKC_group Phospho.ELM 7.0 ViewAnalyzing
4PTGER4PE2R4_HUMANS354CRIGG S RRERS 23.97%PKC_group Phospho.ELM 7.0 ViewAnalyzing
5PTGER4PE2R4_HUMANS374TSSAM S GHSRS 32.82% Phospho.ELM 7.0View   
6PTGER4PE2R4_HUMANS377AMSGH S RSFIS 32.90% Phospho.ELM 7.0View   
7PTGER4PE2R4_HUMANS379SGHSR S FISRE 29.91% Phospho.ELM 7.0View   
8PTGER4PE2R4_HUMANS382SRSFI S RELKE 20.07% Phospho.ELM 7.0View   
9PTGER4PE2R4_HUMANS430QEDTT S LRTLR 20.25%PKC_group Phospho.ELM 7.0 ViewAnalyzing
10PTGER4PE2R4_HUMANT433TTSLR T LRISE 26.19%PKC_group Phospho.ELM 7.0 ViewAnalyzing
11PTGER4PE2R4_HUMANS460DEAGG S GRAGP 24.96%PKC_group Phospho.ELM 7.0 ViewAnalyzing
12PTGER4PE2R4_HUMANS484ETLNL S EKCI 33.66%PKC_group Phospho.ELM 7.0 ViewAnalyzing