Regulatory Network in Protein Phosphorylation
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Substrate: RGS19

Description: Regulator of G-protein signaling 19 (RGS19) (G-alpha-interactingprotein) (GAIP).

Synonyms: GAIP, GNAI3IP

Ensembl ID: ENSG00000171700

UniprotKB/SwissProt: RGS19_HUMAN (P49795)

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Lipid-anchor.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RGS19

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RGS19RGS19_HUMANS24RPPSM S SHDTA 28.94% Swiss-Prot 55.0 (Similarity)View   
2RGS19RGS19_HUMANS24RPPSM S SHDTA 28.94%CK2a1 HPRD:05461(in vivo)  ViewAnalyzing
3RGS19RGS19_HUMANS24RPPSM S SHDTA 28.94%PKC_group Phospho.ELM 7.0 ViewAnalyzing
4RGS19RGS19_HUMANS24RPPSM S SHDTA 28.94%CK2_group Phospho.ELM 7.0 ViewAnalyzing
5RGS19RGS19_HUMANS24RPPSM S SHDTA 28.94%PKCa HPRD:05461(in vivo)  ViewAnalyzing
6RGS19RGS19_HUMANS24RPPSM S SHDTA 28.94%CK2a2 HPRD:05461(in vivo)  ViewAnalyzing
7RGS19RGS19_HUMANS24RPPSM S SHDTA 28.94%CK2a1-rs HPRD:05461(in vivo)  ViewAnalyzing
8RGS19RGS19_HUMANS151YVSIL S PKEVS 32.05%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
9RGS19RGS19_HUMANS151YVSIL S PKEVS 32.05%Erk1(MAPK3) Swiss-Prot 55.0  ViewAnalyzing
10RGS19RGS19_HUMANS151YVSIL S PKEVS 32.05%Erk2 HPRD:05461(in vitro;in vivo)  ViewAnalyzing
11RGS19RGS19_HUMANS151YVSIL S PKEVS 32.05%CK2_group Phospho.ELM 7.0 ViewAnalyzing
12RGS19RGS19_HUMANS151YVSIL S PKEVS 32.05%Erk2(MAPK1) Swiss-Prot 55.0  ViewAnalyzing
13RGS19RGS19_HUMANT201FLSSP T YRALL 27.82%PKCa HPRD:05461(in vivo)  ViewAnalyzing
14RGS19RGS19_HUMANT201FLSSP T YRALL 27.82%PKC_group Phospho.ELM 7.0 ViewAnalyzing