Regulatory Network in Protein Phosphorylation
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Substrate: SLC9A3R1

Description: Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+)exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor ofNa(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1)(Solute carrier family 9 isoform A3 regulatory factor 1).

Synonyms: NHERF

Ensembl ID: ENSG00000109062

UniprotKB/SwissProt: NHERF_HUMAN (O14745)

Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Intracytoplasmic membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruf
PDB:1G9O
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SLC9A3R1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SLC9A3R1NHERF_HUMANS162MKKGP S GYGFN 54.00%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
2SLC9A3R1NHERF_HUMANS269IQKEN S REALA 32.37% Phospho.ELM 7.0View   
3SLC9A3R1NHERF_HUMANS280EAALE S PRPAL 27.36% Swiss-Prot 55.0 View   
4SLC9A3R1NHERF_HUMANS280EAALE S PRPAL 27.36% Phospho.ELM 7.0View   
5SLC9A3R1NHERF_HUMANS288PALVR S ASSDT 25.64% Swiss-Prot 55.0 (Similarity)View   
6SLC9A3R1NHERF_HUMANS290LVRSA S SDTSE 29.96%GPRK6(GRK6) Phospho.ELM 7.0 ViewAnalyzing
7SLC9A3R1NHERF_HUMANS290LVRSA S SDTSE 29.96%GPRK6 HPRD:05406(in vitro;in vivo)  ViewAnalyzing
8SLC9A3R1NHERF_HUMANS290LVRSA S SDTSE 29.96% HPRD:05406(in vivo)View   
9SLC9A3R1NHERF_HUMANS290LVRSA S SDTSE 29.96% Swiss-Prot 55.0 (Similarity)View   
10SLC9A3R1NHERF_HUMANS291VRSAS S DTSEE 44.62% Swiss-Prot 55.0 (Similarity)View   
11SLC9A3R1NHERF_HUMANT293SASSD T SEELN 39.73% Swiss-Prot 55.0 (Similarity)View   
12SLC9A3R1NHERF_HUMANS294ASSDT S EELNS 33.78% Swiss-Prot 55.0 (Similarity)View   
13SLC9A3R1NHERF_HUMANS302LNSQD S PPKQD 35.15% Swiss-Prot 55.0 (Similarity)View