Regulatory Network in Protein Phosphorylation
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Substrate: STAT3

Description: Signal transducer and activator of transcription 3 (Acute-phaseresponse factor).

Synonyms: APRF

Ensembl ID: ENSG00000168610

UniprotKB/SwissProt: STAT3_HUMAN (P40763)

Function: Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of STAT3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1STAT3STAT3_HUMANY657EIIMG Y KIMDA 4.67% HPRD:00026(in vivo)View   
2STAT3STAT3_HUMANY674PLVYL Y PDIPK 4.91% HPRD:00026(in vivo)View   
3STAT3STAT3_HUMANS691YCRPE S QEHPE 43.48% Swiss-Prot 55.0 View   
4STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%FGFR3 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
5STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%JAK1 HPRD:00026(in vivo)  ViewAnalyzing
6STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%JAK1 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
7STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%Src Phospho.ELM 7.0  ViewAnalyzing
8STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%SRC HPRD:00026(in vivo)  ViewAnalyzing
9STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%JAK2 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
10STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%JAK2 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
11STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%SRC HPRD:00026(in vitro;in vivo)  ViewAnalyzing
12STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%JAK2 Phospho.ELM 7.0  ViewAnalyzing
13STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%JAK1 Phospho.ELM 7.0  ViewAnalyzing
14STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%JAK2 HPRD:00026(in vivo)  ViewAnalyzing
15STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%HCK HPRD:00026(in vivo)  ViewAnalyzing
16STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%HCK HPRD:00026(in vitro;in vivo)  ViewAnalyzing
17STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%FGFR3 HPRD:00026(in vivo)  ViewAnalyzing
18STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%FGFR4 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
19STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%Src_group Phospho.ELM 7.0 ViewAnalyzing
20STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99% Swiss-Prot 55.0 View   
21STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%ALK Phospho.ELM 7.0  ViewAnalyzing
22STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%Ret Phospho.ELM 7.0  ViewAnalyzing
23STAT3STAT3_HUMANY705GSAAP Y LKTKF 18.99%FGFR4 HPRD:00026(in vivo)  ViewAnalyzing
24STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%Erk1 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
25STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86% Swiss-Prot 55.0 (Similarity)View   
26STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%PKCd HPRD:00026(in vitro;in vivo)  ViewAnalyzing
27STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%PKCd HPRD:00026(in vitro;in vivo)  ViewAnalyzing
28STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%MSK1 HPRD:00026(in vivo)  ViewAnalyzing
29STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%MSK1 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
30STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%IRAK1 Phospho.ELM 7.0  ViewAnalyzing
31STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%Erk2 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
32STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%JNK1 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
33STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%JNK1 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
34STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%Erk1 HPRD:00026(in vitro;in vivo)  ViewAnalyzing
35STAT3STAT3_HUMANS727IDLPM S PRTLD 14.86%Erk2 HPRD:00026(in vitro;in vivo)  ViewAnalyzing