Regulatory Network in Protein Phosphorylation
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Substrate: STK39

Description: STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1)(Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

Synonyms: SPAK

Ensembl ID: ENSG00000198648

UniprotKB/SwissProt: STK39_HUMAN (Q9UEW8)

Function: May act as a mediator of stress-activated signals.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (Probable). Nucleus (Probable). Note=Nucleus when caspase-cleaved (Probable).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of STK39

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1STK39STK39_HUMANT233NKVRK T FVGTP 17.00%Wnk1 Phospho.ELM 7.0  ViewAnalyzing
2STK39STK39_HUMANS311KKYGK S FRKLL 26.39%PKCt HPRD:09627(in vitro;in vivo)  ViewAnalyzing
3STK39STK39_HUMANS311KKYGK S FRKLL 26.39%PKCt(PKC theta) Phospho.ELM 7.0 ViewAnalyzing
4STK39STK39_HUMANS325LQKDP S KRPTA 51.97%PKCt HPRD:09627(in vitro;in vivo)  ViewAnalyzing
5STK39STK39_HUMANS325LQKDP S KRPTA 51.97%PKCt(PKC theta) Phospho.ELM 7.0 ViewAnalyzing
6STK39STK39_HUMANT356KLLTR T PDIAQ 21.78% Swiss-Prot 55.0 View   
7STK39STK39_HUMANS372RRVPG S SGHLH 27.38% Swiss-Prot 55.0 View   
8STK39STK39_HUMANS373RVPGS S GHLHK 35.83%Wnk1 Phospho.ELM 7.0  ViewAnalyzing
9STK39STK39_HUMANS387GDWEW S DDEMD 24.54% Swiss-Prot 55.0 View