Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinase PKCi]
Substrate: STXBP1

Description: Syntaxin-binding protein 1 (Unc-18 homolog) (Unc-18A) (Unc-18-1) (N-Sec1) (p67).

Synonyms: UNC18A

Ensembl ID: ENSG00000136854

UniprotKB/SwissProt: STXB1_HUMAN (P61764)

Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of STXBP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1STXBP1STXB1_HUMANT107AHVFF T DSCPD 18.62% Swiss-Prot 55.0 (Similarity)View   
2STXBP1STXB1_HUMANS142FLPYE S QVYSL 21.07% Swiss-Prot 55.0 (Similarity)View   
3STXBP1STXB1_HUMANY145YESQV Y SLDSA 8.90% Swiss-Prot 55.0 (Similarity)View   
4STXBP1STXB1_HUMANS146ESQVY S LDSAD 27.18% Swiss-Prot 55.0 (Similarity)View   
5STXBP1STXB1_HUMANS306QEVTR S LKDFS 30.33%PKCb HPRD:04235(in vitro)  ViewAnalyzing
6STXBP1STXB1_HUMANS306QEVTR S LKDFS 30.33%PKCg HPRD:04235(in vitro)  ViewAnalyzing
7STXBP1STXB1_HUMANS306QEVTR S LKDFS 30.33%PKCg HPRD:04235(in vitro)  ViewAnalyzing
8STXBP1STXB1_HUMANS306QEVTR S LKDFS 30.33%PKCa HPRD:04235(in vitro)  ViewAnalyzing
9STXBP1STXB1_HUMANS306QEVTR S LKDFS 30.33%PKCa HPRD:04235(in vitro)  ViewAnalyzing
10STXBP1STXB1_HUMANS306QEVTR S LKDFS 30.33%PKCb HPRD:04235(in vitro)  ViewAnalyzing
11STXBP1STXB1_HUMANS313KDFSS S KRMNT 24.08%PKCa HPRD:04235(in vitro)  ViewAnalyzing
12STXBP1STXB1_HUMANS313KDFSS S KRMNT 24.08%PKCb HPRD:04235(in vitro)  ViewAnalyzing
13STXBP1STXB1_HUMANS313KDFSS S KRMNT 24.08%PKCb HPRD:04235(in vitro;in vivo)  ViewAnalyzing
14STXBP1STXB1_HUMANS313KDFSS S KRMNT 24.08%PKCa HPRD:04235(in vitro;in vivo)  ViewAnalyzing
15STXBP1STXB1_HUMANS313KDFSS S KRMNT 24.08%PKCg HPRD:04235(in vitro)  ViewAnalyzing
16STXBP1STXB1_HUMANS313KDFSS S KRMNT 24.08%PKCg HPRD:04235(in vitro;in vivo)  ViewAnalyzing
17STXBP1STXB1_HUMANS345ELSKY S THLHL 17.06% Swiss-Prot 55.0 (Similarity)View   
18STXBP1STXB1_HUMANT346LSKYS T HLHLA 25.93% Swiss-Prot 55.0 (Similarity)View   
19STXBP1STXB1_HUMANY473ISEQT Y QLSRW 13.72% Swiss-Prot 55.0 View   
20STXBP1STXB1_HUMANS507ISTRS S ASFST 25.33% Swiss-Prot 55.0 (Similarity)View   
21STXBP1STXB1_HUMANS509TRSSA S FSTTA 22.98% Swiss-Prot 55.0 (Similarity)View