|Description: Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen)(T9) (p90) [Contains: Transferrin receptor protein 1, serum form(sTfR)].|
Ensembl ID: ENSG00000072274
UniprotKB/SwissProt: TFR1_HUMAN (P02786)
Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Transferrin receptor protein 1, serum form: Secreted.