Regulatory Network in Protein Phosphorylation
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Substrate: TFRC

Description: Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen)(T9) (p90) [Contains: Transferrin receptor protein 1, serum form(sTfR)].

Ensembl ID: ENSG00000072274

UniprotKB/SwissProt: TFR1_HUMAN (P02786)

Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Transferrin receptor protein 1, serum form: Secreted.
PDB:1CX8
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TFRC

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TFRCTFR1_HUMANY20GEPLS Y TRFSL 15.04% Swiss-Prot 55.0 View   
2TFRCTFR1_HUMANY20GEPLS Y TRFSL 15.04% Phospho.ELM 7.0View   
3TFRCTFR1_HUMANY20GEPLS Y TRFSL 15.04% HPRD:01812(in vivo)View   
4TFRCTFR1_HUMANS24SYTRF S LARQV 20.16% Swiss-Prot 55.0 View   
5TFRCTFR1_HUMANS24SYTRF S LARQV 20.16%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
6TFRCTFR1_HUMANS24SYTRF S LARQV 20.16%PKC_group Phospho.ELM 7.0 ViewAnalyzing
7TFRCTFR1_HUMANS24SYTRF S LARQV 20.16% HPRD:01812(in vitro;in vivo)View