Regulatory Network in Protein Phosphorylation
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Substrate: TRPM4

Description: Transient receptor potential cation channel subfamily M member 4 (Longtransient receptor potential channel 4) (hTRPM4) (Melastatin-4)(Calcium-activated non-selective cation channel 1).

Ensembl ID: ENSG00000130529

UniprotKB/SwissProt: TRPM4_HUMAN (Q8TD43)

Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TRPM4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TRPM4TRPM4_HUMANS1145KRESD S ERLKR 33.62%PKC_group  Swiss-Prot 55.0 (Probable) ViewAnalyzing
2TRPM4TRPM4_HUMANS1152RLKRT S QKVDL 31.85%PKC_group  Swiss-Prot 55.0 (Probable) ViewAnalyzing