|Description: Transient receptor potential cation channel subfamily M member 4 (Longtransient receptor potential channel 4) (hTRPM4) (Melastatin-4)(Calcium-activated non-selective cation channel 1).|
Ensembl ID: ENSG00000130529
UniprotKB/SwissProt: TRPM4_HUMAN (Q8TD43)
Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein.