Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinase PKCi]
Substrate: TRPV1

Description: Transient receptor potential cation channel subfamily V member 1(TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)(Capsaicin receptor).

Synonyms: VR1

Ensembl ID: ENSG00000196689

UniprotKB/SwissProt: TRPV1_HUMAN (Q8NER1)

Function: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TRPV1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TRPV1TRPV1_HUMANS117LYDRR S IFEAV 32.30% Swiss-Prot 55.0 (Similarity)View   
2TRPV1TRPV1_HUMANS117LYDRR S IFEAV 32.30% HPRD:03648(in vitro)View   
3TRPV1TRPV1_HUMANT145SKKHL T DNEFK 36.18%PKCe HPRD:03648(in vitro)  ViewAnalyzing
4TRPV1TRPV1_HUMANT145SKKHL T DNEFK 36.18% Swiss-Prot 55.0 (Similarity)View   
5TRPV1TRPV1_HUMANT371LSRKF T EWAYG 33.38% Swiss-Prot 55.0 (Similarity)View   
6TRPV1TRPV1_HUMANS502LQRRP S MKTLF 30.97% HPRD:03648(in vitro;in vivo)View   
7TRPV1TRPV1_HUMANS502LQRRP S MKTLF 30.97%PKCe HPRD:03648(in vitro;in vivo)  ViewAnalyzing
8TRPV1TRPV1_HUMANS502LQRRP S MKTLF 30.97% Swiss-Prot 55.0 (Similarity)View   
9TRPV1TRPV1_HUMANT705LQRAI T ILDTE 17.95% Swiss-Prot 55.0 (Similarity)View   
10TRPV1TRPV1_HUMANT705LQRAI T ILDTE 17.95%PKCe HPRD:03648(in vitro)  ViewAnalyzing
11TRPV1TRPV1_HUMANT705LQRAI T ILDTE 17.95% HPRD:03648(in vitro;in vivo)View   
12TRPV1TRPV1_HUMANS775VKRTL S FSLRS 16.51% Swiss-Prot 55.0 (Similarity)View   
13TRPV1TRPV1_HUMANS775VKRTL S FSLRS 16.51%PKCe HPRD:03648(in vitro)  ViewAnalyzing
14TRPV1TRPV1_HUMANS801LLREA S ARDRQ 21.05%PKCe HPRD:03648(in vitro;in vivo)  ViewAnalyzing
15TRPV1TRPV1_HUMANS801LLREA S ARDRQ 21.05% Swiss-Prot 55.0 (Similarity)View   
16TRPV1TRPV1_HUMANS821RQFSG S LKPED 31.83%PKCe HPRD:03648(in vitro)  ViewAnalyzing
17TRPV1TRPV1_HUMANS821RQFSG S LKPED 31.83% Swiss-Prot 55.0 (Similarity)View