Regulatory Network in Protein Phosphorylation
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Substrate: TRPV6

Description: Transient receptor potential cation channel subfamily V member 6(TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transportprotein 1) (CaT1) (CaT-like) (CaT-L).

Synonyms: ECAC2

Ensembl ID: ENSG00000165125

UniprotKB/SwissProt: TRPV6_HUMAN (Q9H1D0)

Function: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TRPV6

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TRPV6TRPV6_HUMANT702RLRQG T LRRDL 14.57%PKCa Swiss-Prot 55.0   ViewAnalyzing
2TRPV6TRPV6_HUMANT702RLRQG T LRRDL 14.57%PKCa HPRD:05982(in vitro;in vivo)  ViewAnalyzing
3TRPV6TRPV6_HUMANT702RLRQG T LRRDL 14.57%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing