Regulatory Network in Protein Phosphorylation
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Substrate: VTN

Description: Vitronectin precursor (Serum-spreading factor) (S-protein) (V75)[Contains: Vitronectin V65 subunit; Vitronectin V10 subunit;Somatomedin-B].

Ensembl ID: ENSG00000109072

UniprotKB/SwissProt: VTNC_HUMAN (P04004)

Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space.
PDB:1OC0
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of VTN

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1VTNVTNC_HUMANT69RGDVF T MPEDE 31.50%CK2a1-rs HPRD:01902(in vitro;in vivo)  ViewAnalyzing
2VTNVTNC_HUMANT69RGDVF T MPEDE 31.50%CK2_group Phospho.ELM 7.0 ViewAnalyzing
3VTNVTNC_HUMANT69RGDVF T MPEDE 31.50%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
4VTNVTNC_HUMANT69RGDVF T MPEDE 31.50%CK2_group Swiss-Prot 55.0 (in vitro) ViewAnalyzing
5VTNVTNC_HUMANT69RGDVF T MPEDE 31.50%CK2a1 HPRD:01902(in vitro;in vivo)  ViewAnalyzing
6VTNVTNC_HUMANT76PEDEY T VYDDG 15.56%CK2_group Swiss-Prot 55.0 (in vitro) ViewAnalyzing
7VTNVTNC_HUMANT76PEDEY T VYDDG 15.56%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
8VTNVTNC_HUMANT76PEDEY T VYDDG 15.56%CK2_group Phospho.ELM 7.0 ViewAnalyzing
9VTNVTNC_HUMANT76PEDEY T VYDDG 15.56%CK2a1-rs HPRD:01902(in vitro;in vivo)  ViewAnalyzing
10VTNVTNC_HUMANT76PEDEY T VYDDG 15.56%CK2a1 HPRD:01902(in vitro;in vivo)  ViewAnalyzing
11VTNVTNC_HUMANS171DLKNG S LFAFR 29.70% Swiss-Prot 55.0 View   
12VTNVTNC_HUMANS171DLKNG S LFAFR 29.70% Phospho.ELM 7.0View   
13VTNVTNC_HUMANS312MMQRD S WEDIF 34.26% Swiss-Prot 55.0 View   
14VTNVTNC_HUMANS381RKGYR S QRGHS 18.75%PKCb HPRD:01902(in vitro)  ViewAnalyzing
15VTNVTNC_HUMANS381RKGYR S QRGHS 18.75%PKCg HPRD:01902(in vitro)  ViewAnalyzing
16VTNVTNC_HUMANS381RKGYR S QRGHS 18.75%PKCa HPRD:01902(in vitro)  ViewAnalyzing
17VTNVTNC_HUMANS397NSRRP S RATWL 32.51%PKA_group Phospho.ELM 7.0 ViewAnalyzing
18VTNVTNC_HUMANS397NSRRP S RATWL 32.51%PKA_group Swiss-Prot 55.0  ViewAnalyzing
19VTNVTNC_HUMANS397NSRRP S RATWL 32.51%PKACa HPRD:01902(in vitro)  ViewAnalyzing