Regulatory Network in Protein Phosphorylation
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Substrate: PKN1

Description: Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C-like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-likePKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

Synonyms: PKN, PRK1, PRKCL1

Ensembl ID: ENSG00000123143

UniprotKB/SwissProt: PKN1_HUMAN (Q16512)

Function: Can phosphorylate ribosomal protein S6. Mediates GTPase Rho dependent intracellular signaling (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity).
PDB:1CXZ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PKN1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PKN1PKN1_HUMANT64LRRAT T DLGRS 28.39%PKN1 HPRD:03019(in vitro)  ViewAnalyzing
2PKN1PKN1_HUMANT64LRRAT T DLGRS 28.39%PKN1 HPRD:03019(in vivo)  ViewAnalyzing
3PKN1PKN1_HUMANS372GLYSR S GSLSG 27.13%PKN1 HPRD:03019(in vitro)  ViewAnalyzing
4PKN1PKN1_HUMANS374YSRSG S LSGRS 22.17%PKN1 HPRD:03019(in vitro)  ViewAnalyzing
5PKN1PKN1_HUMANS376RSGSL S GRSSL 33.58% Swiss-Prot 55.0 View   
6PKN1PKN1_HUMANS376RSGSL S GRSSL 33.58% Phospho.ELM 7.0View   
7PKN1PKN1_HUMANS380LSGRS S LKAEA 32.31%PKN1 HPRD:03019(in vivo)  ViewAnalyzing
8PKN1PKN1_HUMANT531ATGTG T FSPGA 22.30%PKN1 HPRD:03019(in vitro)  ViewAnalyzing
9PKN1PKN1_HUMANT531ATGTG T FSPGA 22.30%PKN1 HPRD:03019(in vivo)  ViewAnalyzing
10PKN1PKN1_HUMANS562TDSDS S PQKSS 36.02% Swiss-Prot 55.0 View   
11PKN1PKN1_HUMANS562TDSDS S PQKSS 36.02% Phospho.ELM 7.0View   
12PKN1PKN1_HUMANS576PSSPS S LSSPI 35.34%PKN1 HPRD:03019(in vitro)  ViewAnalyzing
13PKN1PKN1_HUMANS608SPLRK S PLTLE 20.78%PKN1 HPRD:03019(in vitro)  ViewAnalyzing
14PKN1PKN1_HUMANT774GDRTS T FCGTP 23.49%PDK1 HPRD:03019(in vitro)  ViewAnalyzing
15PKN1PKN1_HUMANT774GDRTS T FCGTP 23.49% Swiss-Prot 55.0 (Probable)View   
16PKN1PKN1_HUMANT774GDRTS T FCGTP 23.49%PDK1 HPRD:03019(in vitro;in vivo)  ViewAnalyzing
17PKN1PKN1_HUMANT774GDRTS T FCGTP 23.49%PDK1 Phospho.ELM 7.0  ViewAnalyzing
18PKN1PKN1_HUMANS916EAPTL S PPRDA 35.02% Phospho.ELM 7.0View   
19PKN1PKN1_HUMANS916EAPTL S PPRDA 35.02% Swiss-Prot 55.0 View   
20PKN1PKN1_HUMANS916EAPTL S PPRDA 35.02% HPRD:03019(in vitro)View   
21PKN1PKN1_HUMANS916EAPTL S PPRDA 35.02% HPRD:03019(in vivo)View