Regulatory Network in Protein Phosphorylation
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[Back to Kinase eEF2K]
Substrate: EEF2K

Description: Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K)(Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

Ensembl ID: ENSG00000103319

UniprotKB/SwissProt: EF2K_HUMAN (O00418)

Function: Phosphorylates eukaryotic elongation factor-2. Binds calmodulin (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EEF2K

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EEF2KEF2K_HUMANS18VDGGQ S PRAGH 21.45% Swiss-Prot 55.0 View   
2EEF2KEF2K_HUMANS18VDGGQ S PRAGH 21.45% HPRD:07369(in vitro)View   
3EEF2KEF2K_HUMANS18VDGGQ S PRAGH 21.45% Phospho.ELM 7.0View   
4EEF2KEF2K_HUMANS27GHDGD S DGDSD 49.36% Swiss-Prot 55.0 View   
5EEF2KEF2K_HUMANS31DSDGD S DDEEG 53.11% Swiss-Prot 55.0 View   
6EEF2KEF2K_HUMANY69TKSER Y SSSGS 14.62% Swiss-Prot 55.0 View   
7EEF2KEF2K_HUMANS70KSERY S SSGSP 25.01% Swiss-Prot 55.0 View   
8EEF2KEF2K_HUMANS71SERYS S SGSPA 29.77% Swiss-Prot 55.0 (Similarity)View   
9EEF2KEF2K_HUMANS78GSPAN S FHFKE 23.39%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
10EEF2KEF2K_HUMANS78GSPAN S FHFKE 23.39%AMPKa1 HPRD:07369(in vitro;in vivo)  ViewAnalyzing
11EEF2KEF2K_HUMANS78GSPAN S FHFKE 23.39%AMPKa2 HPRD:07369(in vitro;in vivo)  ViewAnalyzing
12EEF2KEF2K_HUMANS135LIKMA S QPFGR 34.58% Swiss-Prot 55.0 View   
13EEF2KEF2K_HUMANS359EEKCG S PRVRT 21.00%p38d HPRD:07369(in vitro)  ViewAnalyzing
14EEF2KEF2K_HUMANS359EEKCG S PRVRT 21.00%p38d(MAPK13) Phospho.ELM 7.0 ViewAnalyzing
15EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%p70_group Phospho.ELM 7.0 ViewAnalyzing
16EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%RSK3 HPRD:07369(in vitro;in vivo)  ViewAnalyzing
17EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%AMPKa2 HPRD:07369(in vitro;in vivo)  ViewAnalyzing
18EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%PKACa HPRD:07369(in vitro;in vivo)  ViewAnalyzing
19EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%RSK_group Phospho.ELM 7.0 ViewAnalyzing
20EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%AMPKa1 HPRD:07369(in vitro;in vivo)  ViewAnalyzing
21EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
22EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%p70S6K Phospho.ELM 7.0  ViewAnalyzing
23EEF2KEF2K_HUMANS366RVRTL S GSRPP 33.82%p70S6K HPRD:07369(in vitro;in vivo)  ViewAnalyzing
24EEF2KEF2K_HUMANS377LLRPL S ENSGD 37.10%MAPKAPK2 HPRD:07369(in vitro)  ViewAnalyzing
25EEF2KEF2K_HUMANS377LLRPL S ENSGD 37.10%MAPKAPK3 HPRD:07369(in vitro)  ViewAnalyzing
26EEF2KEF2K_HUMANS377LLRPL S ENSGD 37.10%MAPKAPK5 HPRD:07369(in vitro)  ViewAnalyzing
27EEF2KEF2K_HUMANS377LLRPL S ENSGD 37.10%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
28EEF2KEF2K_HUMANS396DSLPS S PSSAT 27.19%eEF2K Phospho.ELM 7.0  ViewAnalyzing
29EEF2KEF2K_HUMANS396DSLPS S PSSAT 27.19%p38a HPRD:07369(in vitro)  ViewAnalyzing
30EEF2KEF2K_HUMANS396DSLPS S PSSAT 27.19%p38g HPRD:07369(in vitro)  ViewAnalyzing
31EEF2KEF2K_HUMANS396DSLPS S PSSAT 27.19%JNK2 HPRD:07369(in vitro)  ViewAnalyzing
32EEF2KEF2K_HUMANS396DSLPS S PSSAT 27.19%JNK1 HPRD:07369(in vitro)  ViewAnalyzing
33EEF2KEF2K_HUMANS396DSLPS S PSSAT 27.19%p38d HPRD:07369(in vitro;in vivo)  ViewAnalyzing
34EEF2KEF2K_HUMANS396DSLPS S PSSAT 27.19%p38b HPRD:07369(in vitro)  ViewAnalyzing
35EEF2KEF2K_HUMANS398LPSSP S SATPH 34.26%AMPKa1 HPRD:07369(in vitro;in vivo)  ViewAnalyzing
36EEF2KEF2K_HUMANS398LPSSP S SATPH 34.26%AMPKa2 HPRD:07369(in vitro;in vivo)  ViewAnalyzing
37EEF2KEF2K_HUMANS398LPSSP S SATPH 34.26%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
38EEF2KEF2K_HUMANS445DSGYP S EKRGE 47.46% Swiss-Prot 55.0 View   
39EEF2KEF2K_HUMANS470NRKYE S DEDSL 43.12% Swiss-Prot 55.0 View   
40EEF2KEF2K_HUMANS470NRKYE S DEDSL 43.12% Phospho.ELM 7.0View   
41EEF2KEF2K_HUMANS474ESDED S LGSSG 32.36% Swiss-Prot 55.0 View   
42EEF2KEF2K_HUMANS474ESDED S LGSSG 32.36% Phospho.ELM 7.0View   
43EEF2KEF2K_HUMANS500HLPRA S AVALE 25.26%PKACa HPRD:07369(in vitro;in vivo)  ViewAnalyzing