Regulatory Network in Protein Phosphorylation
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Substrate: MLLT4

Description: Afadin (Protein AF-6).

Synonyms: AF6

Ensembl ID: ENSG00000130396

UniprotKB/SwissProt: AFAD_HUMAN (P55196)

Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell junction, adherens junction. Note=Not found at cell-matrix AJs.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MLLT4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MLLT4AFAD_HUMANS541TTRLD S DRVSS 31.72% Swiss-Prot 55.0 (Similarity)View   
2MLLT4AFAD_HUMANT893TVAEN T ADELA 27.30% Phospho.ELM 7.0View   
3MLLT4AFAD_HUMANT893TVAEN T ADELA 27.30%BCR HPRD:01164(in vitro)  ViewAnalyzing
4MLLT4AFAD_HUMANS1090LLNQP S PMMQR 18.70% Swiss-Prot 55.0 View   
5MLLT4AFAD_HUMANS1090LLNQP S PMMQR 18.70% Phospho.ELM 7.0View   
6MLLT4AFAD_HUMANS1155RADHR S SPNVA 46.88% Swiss-Prot 55.0 View   
7MLLT4AFAD_HUMANS1155RADHR S SPNVA 46.88% Phospho.ELM 7.0View   
8MLLT4AFAD_HUMANS1156ADHRS S PNVAN 22.05% Swiss-Prot 55.0 View   
9MLLT4AFAD_HUMANS1156ADHRS S PNVAN 22.05% HPRD:01164(in vitro)View   
10MLLT4AFAD_HUMANS1156ADHRS S PNVAN 22.05% Phospho.ELM 7.0View   
11MLLT4AFAD_HUMANS1165ANQPP S PGGKS 42.74% HPRD:01164(in vitro;in vivo)View   
12MLLT4AFAD_HUMANS1165ANQPP S PGGKS 42.74% Phospho.ELM 7.0View   
13MLLT4AFAD_HUMANS1165ANQPP S PGGKS 42.74% Swiss-Prot 55.0 View   
14MLLT4AFAD_HUMANS1184KITSV S TGNLC 30.29% Swiss-Prot 55.0 View   
15MLLT4AFAD_HUMANS1184KITSV S TGNLC 30.29% HPRD:01164(in vivo)View   
16MLLT4AFAD_HUMANS1184KITSV S TGNLC 30.29% Phospho.ELM 7.0View   
17MLLT4AFAD_HUMANY1213TYTRE Y FTFPA 12.48% HPRD:01164(in vitro)View   
18MLLT4AFAD_HUMANS1258QRVTR S QEELR 32.36% Swiss-Prot 55.0 (Similarity)View   
19MLLT4AFAD_HUMANT1313SSKSV T PASTL 21.89% Swiss-Prot 55.0 (Similarity)View   
20MLLT4AFAD_HUMANT1317VTPAS T LTKSG 40.32% Swiss-Prot 55.0 (Similarity)View   
21MLLT4AFAD_HUMANS1681EPPSP S PAPGA 37.72% Swiss-Prot 55.0 View