Regulatory Network in Protein Phosphorylation
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Substrate: BRSK1

Description: BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase)(Serine/threonine kinase SAD-B).

Synonyms: KIAA1811, SAD1

Ensembl ID: ENSG00000160469

UniprotKB/SwissProt: BRSK1_HUMAN (Q8TDC3)

Function: Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)- induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BRSK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BRSK1BRSK1_HUMANT205DSLLE T SCGSP 29.32% Swiss-Prot 55.0 View   
2BRSK1BRSK1_HUMANT205DSLLE T SCGSP 29.32%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
3BRSK1BRSK1_HUMANS209ETSCG S PHYAC 16.90% Swiss-Prot 55.0 (Similarity)View