|Description: Serine/threonine-protein kinase MARK2 (EC 220.127.116.11) (MAP/microtubuleaffinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1homolog).|
Ensembl ID: ENSG00000072518
UniprotKB/SwissProt: MARK2_HUMAN (Q7KZI7)
Function: Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Peripheral membrane protein. Note=Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.