Regulatory Network in Protein Phosphorylation
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Substrate: MARK3

Description: MAP/microtubule affinity-regulating kinase 3 (EC (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonineprotein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinaseSTK10).

Synonyms: CTAK1

Ensembl ID: ENSG00000075413

UniprotKB/SwissProt: MARK3_HUMAN (P27448)

Function: Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MARK3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MARK3MARK3_HUMANT234GGKLD T FCGSP 31.12% Swiss-Prot 55.0 View   
2MARK3MARK3_HUMANT234GGKLD T FCGSP 31.12%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
3MARK3MARK3_HUMANS238DTFCG S PPYAA 24.71% Phospho.ELM 7.0View   
4MARK3MARK3_HUMANS442KQRRY S DHAGP 22.55% Swiss-Prot 55.0 View   
5MARK3MARK3_HUMANS442KQRRY S DHAGP 22.55% Phospho.ELM 7.0View   
6MARK3MARK3_HUMANS492GIAPA S PMLGN 15.13% Swiss-Prot 55.0 View   
7MARK3MARK3_HUMANS492GIAPA S PMLGN 15.13% Phospho.ELM 7.0View   
8MARK3MARK3_HUMANS624TRSRG S TNLFS 17.01% Swiss-Prot 55.0 View   
9MARK3MARK3_HUMANS624TRSRG S TNLFS 17.01% Phospho.ELM 7.0View