Regulatory Network in Protein Phosphorylation
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Substrate: MELK

Description: Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK)(Protein kinase PK38) (hPK38).

Synonyms: KIAA0175

Ensembl ID: ENSG00000165304

UniprotKB/SwissProt: MELK_HUMAN (Q14680)

Function: Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (Potential).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MELK

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MELKMELK_HUMANT167DYHLQ T CCGSL 19.00%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
2MELKMELK_HUMANT478QCLKE T PIKIP 28.82% Swiss-Prot 55.0 (Probable)View   
3MELKMELK_HUMANT478QCLKE T PIKIP 28.82% Phospho.ELM 7.0View   
4MELKMELK_HUMANS505ERRCR S VELDL 24.46% Swiss-Prot 55.0 View   
5MELKMELK_HUMANS505ERRCR S VELDL 24.46% Phospho.ELM 7.0View