Regulatory Network in Protein Phosphorylation
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Substrate: NUAK1

Description: NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related proteinkinase 5).

Synonyms: ARK5, KIAA0537

Ensembl ID: ENSG00000074590

UniprotKB/SwissProt: NUAK1_HUMAN (O60285)

Function: Involved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NUAK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NUAK1NUAK1_HUMANT211DKFLQ T FCGSP 24.04% Swiss-Prot 55.0 View   
2NUAK1NUAK1_HUMANT211DKFLQ T FCGSP 24.04%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
3NUAK1NUAK1_HUMANS215QTFCG S PLYAS 16.95% Swiss-Prot 55.0 (Similarity)View   
4NUAK1NUAK1_HUMANS371RSLKK S KKEND 47.58% Swiss-Prot 55.0 (Similarity)View   
5NUAK1NUAK1_HUMANS380NDFAQ S GQDAV 34.68% Swiss-Prot 55.0 (Similarity)View   
6NUAK1NUAK1_HUMANS600RQRIR S CVSAE 19.25%AKT1(PKB) Swiss-Prot 55.0  ViewAnalyzing
7NUAK1NUAK1_HUMANS600RQRIR S CVSAE 19.25%AKT_group Phospho.ELM 7.0 ViewAnalyzing