|Description: NUAK family SNF1-like kinase 2 (EC 22.214.171.124) (SNF1/AMP kinase-relatedkinase) (SNARK).|
Ensembl ID: ENSG00000163545
UniprotKB/SwissProt: NUAK2_HUMAN (Q9H093)
Function: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: