Regulatory Network in Protein Phosphorylation
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Substrate: NUAK2

Description: NUAK family SNF1-like kinase 2 (EC (SNF1/AMP kinase-relatedkinase) (SNARK).

Synonyms: SNARK

Ensembl ID: ENSG00000163545

UniprotKB/SwissProt: NUAK2_HUMAN (Q9H093)

Function: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NUAK2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NUAK2NUAK2_HUMANT208GKFLQ T FCGSP 24.04% Swiss-Prot 55.0 View   
2NUAK2NUAK2_HUMANT208GKFLQ T FCGSP 24.04%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
3NUAK2NUAK2_HUMANS212QTFCG S PLYAS 16.95% Swiss-Prot 55.0 (Similarity)View   
4NUAK2NUAK2_HUMANS377HSLKK S RKEND 47.17% Swiss-Prot 55.0 (Similarity)View   
5NUAK2NUAK2_HUMANS386NDMAQ S LHSDT 20.64% Swiss-Prot 55.0 (Similarity)View   
6NUAK2NUAK2_HUMANS585LEEPP S EGPGS 66.94% Swiss-Prot 55.0 (Similarity)View