Regulatory Network in Protein Phosphorylation
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Substrate: PRKAA1

Description: 5'-AMP-activated protein kinase catalytic subunit alpha-1(EC (AMPK alpha-1 chain).

Synonyms: AMPK1

Ensembl ID: ENSG00000132356

UniprotKB/SwissProt: AAPK1_HUMAN (Q13131)

Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PRKAA1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PRKAA1AAPK1_HUMANT174GEFLR T SCGSP 30.43%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
2PRKAA1AAPK1_HUMANT174GEFLR T SCGSP 30.43%CaMKK1 Phospho.ELM 7.0  ViewAnalyzing
3PRKAA1AAPK1_HUMANT174GEFLR T SCGSP 30.43%CaMKK2 Phospho.ELM 7.0  ViewAnalyzing
4PRKAA1AAPK1_HUMANT174GEFLR T SCGSP 30.43% HPRD:04115(in vitro)View   
5PRKAA1AAPK1_HUMANT174GEFLR T SCGSP 30.43%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
6PRKAA1AAPK1_HUMANT174GEFLR T SCGSP 30.43%LKB1(STK11)  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
7PRKAA1AAPK1_HUMANS175EFLRT S CGSPN 15.28% Swiss-Prot 55.0 (Similarity)View   
8PRKAA1AAPK1_HUMANS487PQRSG S VSNYR 24.50% Phospho.ELM 7.0View   
9PRKAA1AAPK1_HUMANS487PQRSG S VSNYR 24.50% Swiss-Prot 55.0 View   
10PRKAA1AAPK1_HUMANS499CQRSD S DAEAQ 39.71% Swiss-Prot 55.0 (Similarity)View