|Description: 5'-AMP-activated protein kinase catalytic subunit alpha-1(EC 184.108.40.206) (AMPK alpha-1 chain).|
Ensembl ID: ENSG00000132356
UniprotKB/SwissProt: AAPK1_HUMAN (Q13131)
Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: