Regulatory Network in Protein Phosphorylation
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Substrate: PRKAA2

Description: 5'-AMP-activated protein kinase catalytic subunit alpha-2(EC 2.7.11.1) (AMPK alpha-2 chain).

Synonyms: AMPK, AMPK2

Ensembl ID: ENSG00000162409

UniprotKB/SwissProt: AAPK2_HUMAN (P54646)

Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:2H6D
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PRKAA2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PRKAA2AAPK2_HUMANT172GEFLR T SCGSP 30.43%LKB1(STK11)  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2PRKAA2AAPK2_HUMANT172GEFLR T SCGSP 30.43% HPRD:02735(in vitro)View   
3PRKAA2AAPK2_HUMANT172GEFLR T SCGSP 30.43%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
4PRKAA2AAPK2_HUMANS173EFLRT S CGSPN 15.28% Swiss-Prot 55.0 (Similarity)View   
5PRKAA2AAPK2_HUMANS500LHRPR S SFDST 37.73% Swiss-Prot 55.0 (Similarity)View