Regulatory Network in Protein Phosphorylation
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Substrate: SNF1LK

Description: Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1)(Serine/threonine-protein kinase SNF1LK) (Salt-inducible kinase 1)(SIK-1) (SIK1).

Synonyms: SIK

Ensembl ID: ENSG00000142178

UniprotKB/SwissProt: SN1L1_HUMAN (P57059)

Function: Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SNF1LK

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SNF1LKSN1L1_HUMANT182GEPLS T WCGSP 32.24% Swiss-Prot 55.0 View   
2SNF1LKSN1L1_HUMANT182GEPLS T WCGSP 32.24%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
3SNF1LKSN1L1_HUMANS186STWCG S PPYAA 21.40% Swiss-Prot 55.0 (Similarity)View   
4SNF1LKSN1L1_HUMANT460EEEQD T QESLP 33.65% Swiss-Prot 55.0 View   
5SNF1LKSN1L1_HUMANT479LAEVS T RLSPL 40.58% Swiss-Prot 55.0 View   
6SNF1LKSN1L1_HUMANS578RASDT S LTQGL 34.12% Swiss-Prot 55.0 (Similarity)View