|Description: Serine/threonine-protein kinase SNF1-like kinase 1 (EC 22.214.171.124)(Serine/threonine-protein kinase SNF1LK) (Salt-inducible kinase 1)(SIK-1) (SIK1).|
Ensembl ID: ENSG00000142178
UniprotKB/SwissProt: SN1L1_HUMAN (P57059)
Function: Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.