Regulatory Network in Protein Phosphorylation
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Substrate: SNF1LK2

Description: Serine/threonine-protein kinase SNF1-like kinase 2 (EC (Qin-induced kinase) (Salt-inducible protein kinase 2) (SIK-2) (SIK2).

Synonyms: KIAA0781, QIK, SIK2

Ensembl ID: ENSG00000170145

UniprotKB/SwissProt: SN1L2_HUMAN (Q9H0K1)

Function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SNF1LK2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SNF1LK2SN1L2_HUMANT175GELLA T WCGSP 22.66% Swiss-Prot 55.0 View   
2SNF1LK2SN1L2_HUMANT175GELLA T WCGSP 22.66%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
3SNF1LK2SN1L2_HUMANS179ATWCG S PPYAA 21.40% Swiss-Prot 55.0 (Similarity)View   
4SNF1LK2SN1L2_HUMANS587EGRRA S DTSLT 39.34% Swiss-Prot 55.0 (Similarity)View