Regulatory Network in Protein Phosphorylation
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Substrate: STK11

Description: Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine-protein kinase LKB1) (Renal carcinoma antigen NY-REN-19).

Synonyms: LKB1, PJS

Ensembl ID: ENSG00000118046

UniprotKB/SwissProt: STK11_HUMAN (Q15831)

Function: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of STK11

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1STK11STK11_HUMANS31IHRID S TEVIY 24.89% Swiss-Prot 55.0 (Similarity)View   
2STK11STK11_HUMANS31IHRID S TEVIY 24.89% HPRD:03740(in vitro;in vivo)View   
3STK11STK11_HUMANT189LTTGG T LKISD 26.65%LKB1 HPRD:03740(in vitro)  ViewAnalyzing
4STK11STK11_HUMANT189LTTGG T LKISD 26.65%LKB1(STK11) Phospho.ELM 7.0 ViewAnalyzing
5STK11STK11_HUMANS325VPIPP S PDTKD 30.01% HPRD:03740(in vitro;in vivo)View   
6STK11STK11_HUMANT336RWRSM T VVPYL 21.43%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
7STK11STK11_HUMANT336RWRSM T VVPYL 21.43% HPRD:03740(in vitro)View   
8STK11STK11_HUMANT363DDIIY T QDFTV 15.97%ATM HPRD:03740(in vitro;in vivo)  ViewAnalyzing
9STK11STK11_HUMANT363DDIIY T QDFTV 15.97%ATM Phospho.ELM 7.0  ViewAnalyzing
10STK11STK11_HUMANT363DDIIY T QDFTV 15.97%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
11STK11STK11_HUMANS428KIRRL S ACKQQ 29.79%PKACa HPRD:03740(in vitro;in vivo)  ViewAnalyzing
12STK11STK11_HUMANS428KIRRL S ACKQQ 29.79%p70S6K HPRD:03740(in vitro;in vivo)  ViewAnalyzing
13STK11STK11_HUMANS428KIRRL S ACKQQ 29.79%RSK_group Phospho.ELM 7.0 ViewAnalyzing
14STK11STK11_HUMANS428KIRRL S ACKQQ 29.79%MSK1 HPRD:03740(in vitro)  ViewAnalyzing
15STK11STK11_HUMANS428KIRRL S ACKQQ 29.79%PKA_group Swiss-Prot 55.0 (Potential) ViewAnalyzing
16STK11STK11_HUMANS428KIRRL S ACKQQ 29.79%RSK2 HPRD:03740(in vitro;in vivo)  ViewAnalyzing