Regulatory Network in Protein Phosphorylation
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Substrate: AMPH

Description: Amphiphysin.

Synonyms: AMPH1

Ensembl ID: ENSG00000078053

UniprotKB/SwissProt: AMPH_HUMAN (P49418)

Function: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
PDB:1KY7
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of AMPH

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1AMPHAMPH_HUMANS250IQGAP S DSGPL 43.82% Swiss-Prot 55.0 (Similarity)View   
2AMPHAMPH_HUMANS272PSPLP S PTASP 42.43%CDK5 HPRD:02687(in vitro)  ViewAnalyzing
3AMPHAMPH_HUMANS272PSPLP S PTASP 42.43%CDC2 HPRD:02687(in vitro)  ViewAnalyzing
4AMPHAMPH_HUMANS272PSPLP S PTASP 42.43%CDK_group Phospho.ELM 7.0 ViewAnalyzing
5AMPHAMPH_HUMANS276PSPTA S PNHTL 28.81%CDC2 HPRD:02687(in vitro)  ViewAnalyzing
6AMPHAMPH_HUMANS276PSPTA S PNHTL 28.81%CDK_group Phospho.ELM 7.0 ViewAnalyzing
7AMPHAMPH_HUMANS276PSPTA S PNHTL 28.81%CDK5 HPRD:02687(in vitro)  ViewAnalyzing
8AMPHAMPH_HUMANS285TLAPA S PAPAR 22.12%CDK5 HPRD:02687(in vitro)  ViewAnalyzing
9AMPHAMPH_HUMANS285TLAPA S PAPAR 22.12%CDK_group Phospho.ELM 7.0 ViewAnalyzing
10AMPHAMPH_HUMANS285TLAPA S PAPAR 22.12%CDC2 HPRD:02687(in vitro)  ViewAnalyzing
11AMPHAMPH_HUMANS506AGEGV S LEEAK 40.70% Swiss-Prot 55.0 (Similarity)View   
12AMPHAMPH_HUMANS506AGEGV S LEEAK 40.70% HPRD:02687(in vivo)View