Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinase CDK2]
Substrate: BIRC5

Description: Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitorsurvivin) (Apoptosis inhibitor 4).

Synonyms: API4, IAP4

Ensembl ID: ENSG00000089685

UniprotKB/SwissProt: BIRC5_HUMAN (O15392)

Function: May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti- apoptotic effects when compared with the displayed wild-type isoform.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromoso
PDB:1E31
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BIRC5

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BIRC5BIRC5_HUMANT34EGCAC T PERMA 15.06%CDC2 Swiss-Prot 55.0   ViewAnalyzing
2BIRC5BIRC5_HUMANT34EGCAC T PERMA 15.06%CDC2 HPRD:04520(in vitro;in vivo)  ViewAnalyzing
3BIRC5BIRC5_HUMANT34EGCAC T PERMA 15.06%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
4BIRC5BIRC5_HUMANT117KIAKE T NNKKK 43.30%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing