Regulatory Network in Protein Phosphorylation
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Substrate: BUB1

Description: Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1)(hBUB1) (BUB1A).

Synonyms: BUB1L

Ensembl ID: ENSG00000169679

UniprotKB/SwissProt: BUB1_HUMAN (O43683)

Function: Involved in cell cycle checkpoint enforcement. Can interact and phosphorylate BUB3.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Kinetochore (By similarity). Note=Nuclear in interphase cells. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BUB1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BUB1BUB1_HUMANS314EDLPA S QERSE 30.54% Swiss-Prot 55.0 View   
2BUB1BUB1_HUMANT609AQLAS T PFHKL 25.11%CDC2 HPRD:03907(in vitro)  ViewAnalyzing