Regulatory Network in Protein Phosphorylation
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Substrate: CABLES1

Description: CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

Synonyms: CABLES

Ensembl ID: ENSG00000134508

UniprotKB/SwissProt: CABL1_HUMAN (Q8TDN4)

Function: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth c
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CABLES1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CABLES1CABL1_HUMANS168ARGFA S PLGAG 20.56% Swiss-Prot 55.0 View   
2CABLES1CABL1_HUMANS313RTLSG S PRPKN 17.85%CDK2 Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
3CABLES1CABL1_HUMANS313RTLSG S PRPKN 17.85%CDK3 Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
4CABLES1CABL1_HUMANS313RTLSG S PRPKN 17.85%CDK3 HPRD:16461(in vitro;in vivo)  ViewAnalyzing
5CABLES1CABL1_HUMANS313RTLSG S PRPKN 17.85%P24864(Cyclin E1) HPRD:16461(in vitro;in vivo) ViewAnalyzing