Regulatory Network in Protein Phosphorylation
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Substrate: CDC25A

Description: M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25A).

Ensembl ID: ENSG00000164045

UniprotKB/SwissProt: MPIP1_HUMAN (P30304)

Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1C25
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CDC25A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CDC25AMPIP1_HUMANS18LLFAC S PPPAS 36.69%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
2CDC25AMPIP1_HUMANS18LLFAC S PPPAS 36.69%CDC2 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
3CDC25AMPIP1_HUMANS76LQRMG S SESTD 22.91%CHK1 Swiss-Prot 55.0   ViewAnalyzing
4CDC25AMPIP1_HUMANS76LQRMG S SESTD 22.91%CHK1 Phospho.ELM 7.0  ViewAnalyzing
5CDC25AMPIP1_HUMANS76LQRMG S SESTD 22.91% HPRD:00305(in vitro;in vivo)View   
6CDC25AMPIP1_HUMANS79MGSSE S TDSGF 39.19% Phospho.ELM 7.0View   
7CDC25AMPIP1_HUMANS82SESTD S GFCLD 33.58% Phospho.ELM 7.0View   
8CDC25AMPIP1_HUMANS88GFCLD S PGPLD 20.86% Phospho.ELM 7.0View   
9CDC25AMPIP1_HUMANS116KLLGC S PALKR 16.06%CDC2 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
10CDC25AMPIP1_HUMANS116KLLGC S PALKR 16.06%PIM1 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
11CDC25AMPIP1_HUMANS116KLLGC S PALKR 16.06%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
12CDC25AMPIP1_HUMANS116KLLGC S PALKR 16.06%PIM1 Phospho.ELM 7.0  ViewAnalyzing
13CDC25AMPIP1_HUMANS124LKRSH S DSLDH 30.09%CHK2 Phospho.ELM 7.0  ViewAnalyzing
14CDC25AMPIP1_HUMANS124LKRSH S DSLDH 30.09%CHK1 Phospho.ELM 7.0  ViewAnalyzing
15CDC25AMPIP1_HUMANS124LKRSH S DSLDH 30.09%CHK1 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
16CDC25AMPIP1_HUMANS124LKRSH S DSLDH 30.09%CHK2 Swiss-Prot 55.0   ViewAnalyzing
17CDC25AMPIP1_HUMANS124LKRSH S DSLDH 30.09%CHK1 Swiss-Prot 55.0   ViewAnalyzing
18CDC25AMPIP1_HUMANS178TQRQN S APARM 27.56%CHK1 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
19CDC25AMPIP1_HUMANS178TQRQN S APARM 27.56%CHK1 Phospho.ELM 7.0  ViewAnalyzing
20CDC25AMPIP1_HUMANS178TQRQN S APARM 27.56%CHK2 Phospho.ELM 7.0  ViewAnalyzing
21CDC25AMPIP1_HUMANS178TQRQN S APARM 27.56%CHK1 Swiss-Prot 55.0   ViewAnalyzing
22CDC25AMPIP1_HUMANS178TQRQN S APARM 27.56%CHK2 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
23CDC25AMPIP1_HUMANS239PSCMA S LWTAP 9.50%CHK2 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
24CDC25AMPIP1_HUMANS239PSCMA S LWTAP 9.50%CHK1 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
25CDC25AMPIP1_HUMANS279KRPER S QEESP 40.04%CHK2 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
26CDC25AMPIP1_HUMANS279KRPER S QEESP 40.04%CHK2 Phospho.ELM 7.0  ViewAnalyzing
27CDC25AMPIP1_HUMANS279KRPER S QEESP 40.04%CHK1 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
28CDC25AMPIP1_HUMANS279KRPER S QEESP 40.04%CHK2 Swiss-Prot 55.0   ViewAnalyzing
29CDC25AMPIP1_HUMANS279KRPER S QEESP 40.04%CHK1 Swiss-Prot 55.0   ViewAnalyzing
30CDC25AMPIP1_HUMANS279KRPER S QEESP 40.04%CHK1 Phospho.ELM 7.0  ViewAnalyzing
31CDC25AMPIP1_HUMANS293TKRRK S MSGAS 19.17%CHK2 Swiss-Prot 55.0   ViewAnalyzing
32CDC25AMPIP1_HUMANS293TKRRK S MSGAS 19.17%CHK1 Phospho.ELM 7.0  ViewAnalyzing
33CDC25AMPIP1_HUMANS293TKRRK S MSGAS 19.17%CHK2 Phospho.ELM 7.0  ViewAnalyzing
34CDC25AMPIP1_HUMANS293TKRRK S MSGAS 19.17%CHK2 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
35CDC25AMPIP1_HUMANS293TKRRK S MSGAS 19.17%CHK1 HPRD:00305(in vitro;in vivo)  ViewAnalyzing
36CDC25AMPIP1_HUMANS293TKRRK S MSGAS 19.17%CHK1 Swiss-Prot 55.0   ViewAnalyzing
37CDC25AMPIP1_HUMANT507RTKSR T WAGEK 27.10%CHK1 Swiss-Prot 55.0   ViewAnalyzing
38CDC25AMPIP1_HUMANT507RTKSR T WAGEK 27.10%CHK1 Phospho.ELM 7.0  ViewAnalyzing