Regulatory Network in Protein Phosphorylation
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Substrate: CDC6

Description: Cell division control protein 6 homolog (CDC6-related protein)(p62(cdc6)) (HsCDC6) (HsCDC18).

Synonyms: CDC18L

Ensembl ID: ENSG00000094804

UniprotKB/SwissProt: CDC6_HUMAN (Q99741)

Function: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells.
PDB:2CCH
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CDC6

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CDC6CDC6_HUMANS54KALPL S PRKRL 22.25%CDK2 HPRD:04022(in vitro;in vivo)  ViewAnalyzing
2CDC6CDC6_HUMANS54KALPL S PRKRL 22.25%CDK2 Phospho.ELM 7.0  ViewAnalyzing
3CDC6CDC6_HUMANS74HLPPC S PPKQG 50.43%CDK2 HPRD:04022(in vitro;in vivo)  ViewAnalyzing
4CDC6CDC6_HUMANS74HLPPC S PPKQG 50.43%CDK2 Phospho.ELM 7.0  ViewAnalyzing
5CDC6CDC6_HUMANS106QLTIK S PSKRE 30.47%CDK2 HPRD:04022(in vitro;in vivo)  ViewAnalyzing
6CDC6CDC6_HUMANS106QLTIK S PSKRE 30.47%CDK2 Phospho.ELM 7.0  ViewAnalyzing
7CDC6CDC6_HUMANT166KLVLN T AVPDR 25.52% Swiss-Prot 55.0 View