Regulatory Network in Protein Phosphorylation
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Substrate: CDK7

Description: Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complexkinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

Synonyms: MO15

Ensembl ID: ENSG00000134058

UniprotKB/SwissProt: CDK7_HUMAN (P50613)

Function: Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1LG3
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CDK7

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CDK7CDK7_HUMANS164AKSFG S PNRAY 19.59% Swiss-Prot 55.0 View   
2CDK7CDK7_HUMANS164AKSFG S PNRAY 19.59%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
3CDK7CDK7_HUMANS164AKSFG S PNRAY 19.59%CDC2 HPRD:15993(in vitro)  ViewAnalyzing
4CDK7CDK7_HUMANS164AKSFG S PNRAY 19.59%CDK7 Phospho.ELM 7.0  ViewAnalyzing
5CDK7CDK7_HUMANS164AKSFG S PNRAY 19.59%CDK2 Phospho.ELM 7.0  ViewAnalyzing
6CDK7CDK7_HUMANS164AKSFG S PNRAY 19.59%CDK2 HPRD:15993(in vitro)  ViewAnalyzing
7CDK7CDK7_HUMANT170PNRAY T HQVVT 12.59% Swiss-Prot 55.0 View   
8CDK7CDK7_HUMANT170PNRAY T HQVVT 12.59%CDK2 HPRD:15993(in vitro)  ViewAnalyzing
9CDK7CDK7_HUMANT170PNRAY T HQVVT 12.59%CDK2 Phospho.ELM 7.0  ViewAnalyzing
10CDK7CDK7_HUMANT170PNRAY T HQVVT 12.59%CDK7 Phospho.ELM 7.0  ViewAnalyzing
11CDK7CDK7_HUMANT170PNRAY T HQVVT 12.59%CDC2 HPRD:15993(in vitro)  ViewAnalyzing
12CDK7CDK7_HUMANT170PNRAY T HQVVT 12.59%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing