Regulatory Network in Protein Phosphorylation
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Substrate: CDKN1A

Description: Cyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1)(Melanoma differentiation-associated protein 6) (MDA-6).

Synonyms: CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1

Ensembl ID: ENSG00000124762

UniprotKB/SwissProt: CDN1A_HUMAN (P38936)

Function: May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus.
PDB:1AXC
Protein Domain and Phosphorylation Sites: