Regulatory Network in Protein Phosphorylation
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Substrate: CEP110

Description: Centrosomal protein of 110 kDa (Cep110).

Synonyms: CP110, KIAA0419

Ensembl ID: ENSG00000103540

UniprotKB/SwissProt: CE110_HUMAN (O43303)

Function: Necessary for centrosome duplication. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and centrin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Centrosome.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CEP110

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CEP110CE110_HUMANS45GVAIL S PLLNI 13.85%CDK2 HPRD:10848(in vitro)  ViewAnalyzing
2CEP110CE110_HUMANS170SEGFN S PKQCD 31.08%CDK2 HPRD:10848(in vitro)  ViewAnalyzing
3CEP110CE110_HUMANT194KTSSA T PQETL 27.70%CDK2 HPRD:10848(in vitro)  ViewAnalyzing
4CEP110CE110_HUMANS366YAKLP S PEPSM 52.94%CDK2 HPRD:10848(in vitro)  ViewAnalyzing
5CEP110CE110_HUMANS372PEPSM S PKMHR 26.21%CDK2 HPRD:10848(in vitro)  ViewAnalyzing
6CEP110CE110_HUMANS400NACEL S PKGKE 11.41%CDK2 HPRD:10848(in vitro)  ViewAnalyzing
7CEP110CE110_HUMANS516SQCIA S PNFGT 10.64%CDK2 HPRD:10848(in vitro)  ViewAnalyzing
8CEP110CE110_HUMANT566RQQMD T PMVSC 14.13%CDK2 HPRD:10848(in vitro)  ViewAnalyzing
9CEP110CE110_HUMANS641TSSKE S EELLK 39.86% Swiss-Prot 55.0 View