Regulatory Network in Protein Phosphorylation
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Substrate: COIL

Description: Coilin (p80).

Synonyms: CLN80

Ensembl ID: ENSG00000121058

UniprotKB/SwissProt: P80C_HUMAN (P38432)

Function: Makes part of the nuclear coiled bodies (CBS) which are connected with some aspect of the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis cbs disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Nuclear coiled body located in the interchromatin space between the nucleolus and the nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of COIL

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1COILP80C_HUMANT122EEGEE T EPDCK 48.82% HPRD:02605(in vivo)View   
2COILP80C_HUMANT122EEGEE T EPDCK 48.82% Swiss-Prot 55.0 View   
3COILP80C_HUMANT122EEGEE T EPDCK 48.82% Phospho.ELM 7.0View   
4COILP80C_HUMANS184EAKRK S PKKKE 46.08%CDK2 Phospho.ELM 7.0  ViewAnalyzing
5COILP80C_HUMANS184EAKRK S PKKKE 46.08%CDK2 HPRD:02605(in vitro;in vivo)  ViewAnalyzing
6COILP80C_HUMANS202AKNPK S PKVQA 31.07% Phospho.ELM 7.0View   
7COILP80C_HUMANS202AKNPK S PKVQA 31.07% HPRD:02605(in vitro)View   
8COILP80C_HUMANT303LGFSL T PSKGK 25.07% Swiss-Prot 55.0 View   
9COILP80C_HUMANT303LGFSL T PSKGK 25.07% Phospho.ELM 7.0View   
10COILP80C_HUMANT303LGFSL T PSKGK 25.07% HPRD:02605(in vivo)View   
11COILP80C_HUMANS489LTSSY S PDVSD 19.30% Swiss-Prot 55.0 View   
12COILP80C_HUMANS566RLIIE S PSNTS 24.18% Phospho.ELM 7.0View   
13COILP80C_HUMANS566RLIIE S PSNTS 24.18% HPRD:02605(in vivo)View